Sep 06, 2019 primaxin imipenem and cilastatin for injection, for intravenous use initial u. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. This ed material has been downloaded from a licensed data provider and is not for distribution, except. The entry for potassium should list any compatability issues. Primaxin iv belongs to a group of medicines called carbapenem antibiotics. Primaxin iv injection patient information leaflet pil emc. The dry powder should be stored at a temperature below 25c 77f. Imipenem and cilastatin for injection is a sterile formulation of. Knowledge of drug compatibility is needed before mixing drugs. Infiltration is the inadvertent administration of a nonvesicant solution or medication into the tissue surrounding the iv catheter, whereas extravasa. Primaxin iv 500mg500mg powder for solution for infusion. Ysite injection drug compatibility chart for general wards. An equivalent amount of cilastatin is also present in the solution.
Primaxin trade name for a parenteral antibiotic antibiotic, antibiotic drug a chemical substance derivable from a mold or bacterium that can. Primaxin is not recommended in pediatric patients with cns infections because of the risk of seizures see dosage and administration 2. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Imipenemcilastatin, sold under the brand name primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Check tubing below ysite carefully for discoloration, cloudiness or precipitation blank do not mix. What happens if i overdose primaxin im, primaxin iv, primaxin iv addvantage. Primaxin iv 500 mg500 mg powder for solution for infusion. Primaxin iv fda prescribing information, side effects. Its not the same as saline, although the two serve similar purposes. Selected from data included with permission and ed by first databank, inc. That is what they are for and they have quick computer access to those issues.
Antimicrobial use guidelines university of wisconsin. Your doctor will decide how much primaxin iv you need. It works by killing bacteria or preventing their growth. Compatibility of imipenemcilastatin sodium with commonly used intravenous solutions. Read all of this leaflet carefully before you start using this medicine because it contains important information for you. Or call your pharmacist in the facility if you have problems. Compatibility, reconstitution, and stability compatibility and stability. Dont try to find the iv fluid with potassium it isnt there. Treatment of uncomplicated skin and skin structure infections. Reference texts can provide information, but data are often unavailable for new drugs. Dailymed primaxin iv imipenem and cilastatin sodium. Solutions of primaxin range from colourless to yellow.
Follow all directions on your medicine label and package. Intravenous iv preparation and infusion guidelines globalrph. Authored under the editorial authority of ahfs drug information and published by ashp, its the global gold standard for iv compatibility and stability information. Imipenem and cilastatin for injection is a sterile formulation of imipenem a thienamycin antibiotic. Imipenem and cilastatin for injection is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase i, with sodium bicarbonate added as a buffer. It is made from a combination of imipenem and cilastatin. This medicine will not work for colds, flu, or other virus infections. This medication is used to treat a wide variety of bacterial infections. Primaxin imipenem and cilastatin for injection, for intravenous use initial u. Critical care intravenous drug administration guide. Drug name compatibility incompatibile with abciximab.
Severe utis due to escherichia coli or klebsiella pneumoniae. Primaxin definition of primaxin by the free dictionary. The total daily dosage for intravenous imipenemcilastatin should be based on the type or. Mar 20, 2015 preventive strategies always check for compatibility standardize protocol for drug preparation check for alternative modes of administration separation of drug doses by time and place usage of multilumen catheters use inline filters 18. Less than or equal to 3 months of age greater than or equal to 1,500 g body weight 4 weeks to 3 months of age. Device indications for use contraindications midline catheters indicated for short or long term peripheral access to the peripheral venous system for selected intravenous therapies and blood sampling. Pn solutions are diverse in their composition and compatibilities with drugs can never be guaranteed. Primaxin is buffered to provide solutions in the ph range of 6.
Incompatibilities are based on meeting any of the following criteria. Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intraabdominal infections, and urinary tract infections. Infiltration and extravasation lynn hadaway associates. As needed, contact the pharmacist, who has access to more detailed references. Handbook on injectable drugs, 20th edition ahfs drug. Each monograph contains stability data, administration guidelines, and methods of preparation.
Imipenem cilastatin compatibility reconstitution and stability. Imipenemcilastatin primaxin intravenous iv dilution. Feb 06, 2020 what is the most important information i should know about imipenem and cilastatin primaxin im, primaxin iv, primaxin iv addvantage. Primaxin im, primaxin iv, primaxin iv addvantage imipenem. Both complications involve accidental leakage of an iv solution into surrounding tissue, but the type of iv solution differs. Jan 01, 2017 imipenem and cilastatin combination is used in the treatment of infections caused by bacteria. Having easy access to this information saves valuable time by reducing the need to call the pharmacy and provides nurses valuable information to confirm and verify drug compatibility questions prior to patient administration. Add 2 ml or 3 ml of 1% lidocaine hcl solution without epinephrine, respectively, to the 500 mg vial or the 750 mg vial. If you have to mix drugs, follow the drug manufacturers. Primaxin iv fda prescribing information, side effects and uses. Buy primaxin iv imipenem cilastatin sodium online blink. Azactam aztreonam dosing, indications, interactions. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a.
There is no significant change in ph when solutions are prepared and used as directed. This medication is known as a carbapenemtype antibiotic. For blood therapy, it is recommended that a 4 french or. Capitals indicate lifethreatening, underlines indicate most frequent. The dose recommendations for primaxin represent the quantity of imipenemcilastatin to be administered. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. Primaxin is not indicated in patients with meningitis because safety and efficacy have not been established. Primaxin has been found to be stable in sodium chloride 0. Primaxin iv 500mg500mg powder for solution for infusion imipenem cilastatin. Stability and compatibility of vancomycin for administration. Each 125 mg, 250 mg, or 500 mg dose should be given by intravenous administration over 20 to 30 minutes. Primaxin imipenem and cilastatin for injection is a sterile formulation of imipenem, a penem antibacterial, and cilastatin, a renal dehydropeptidase inhibitor with sodium bicarbonate added as a buffer. At nurses stations, the wall charts provide iv compatibility information at the point of care.
The most discussed change in parenteral nutrition compatibility within the last two years was with ceftriaxone. For blood therapy, it is recommended that a 4 french or larger catheter be used. What should i avoid while using imipenem and cilastatin primaxin im, primaxin iv, primaxin iv addvantage. Each 750 mg or mg dose should be infused over 40 to 60 minutes. Antimicrobial cost table cost information current as of march 2011 drug form dose daily cost dose daily cost cefazolin 1 g inj 1 g q8 1. Imipenem and cilastatin for injection is a sterile formulation of imipenem a thienamycin antibiotic and cilastatin sodium the inhibitor of the renal dipeptidase, dehydropeptidase l, with sodium bicarbonate added as a buffer. Primaxin synonyms, primaxin pronunciation, primaxin translation, english dictionary definition of primaxin. Primaxin is an antibacterial drug for intravenous administration. This medication is given by injection into a muscle or vein, usually every 6 to 8 hours or as directed by your doctor. Imipenemcilastatin by injection national library of.
Using the chart, you can doublecheck whether two drugs can be given in the same i. Additive compatibility drugs in syringe compatibility. The daily dose of primaxin should be based on the type of infection and given in equally divided doses based on consideration of degree of susceptibility of the pathogens and the patients renal function see also section 4. If drugs are mixed together, the mixture should be inspected for precipitates, turbidity or changes in colour, however not all incompatibilities are visible. Treatment of complicated intraabdominal infections. Keep a medication compatibility chart handy to help you reduce the chance of i. Variations of color within this range do not affect the potency of the product.
Maxipime cefepime dosing, indications, interactions. Primaxin, as supplied in vials or in addvantage vials and reconstituted as above maintains satisfactory potency for 4 hours at room temperature and for 24 hours under refrigeration 4c. Trissel, fashp, 2010, american society of healthsystem pharmacists. Primaxin iv will be prepared and given to you by a doctor or another health care professional. To mix or not to mix compatibilities of parenteral drug. Ns or d5w preferred diluent for acetaminophen overdose acyclovir. Preferred for doses 1 g or in patients with severe lifethreatening infections. Lactated ringers solution is commonly used as an iv treatment for dehydration or acidbase imbalances.
Ysite compatibility of medications with parenteral nutrition. Primaxin iv injection patient information leaflet pil. Seek emergency medical attention or call the poison help line at 18002221222. S, congest,premarin estrogens,conjugatedsynthetic,a cenestin estrogens,conjugatedsynthetic,b enjuvia classi.
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